A Unified Approach to Targeting the Lysosome's Degradative and Growth Signaling Roles
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چکیده
منابع مشابه
A Unified Approach to Targeting the Lysosome's Degradative and Growth Signaling Roles.
Lysosomes serve dual roles in cancer metabolism, executing catabolic programs (i.e., autophagy and macropinocytosis) while promoting mTORC1-dependent anabolism. Antimalarial compounds such as chloroquine or quinacrine have been used as lysosomal inhibitors, but fail to inhibit mTOR signaling. Further, the molecular target of these agents has not been identified. We report a screen of novel dime...
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ژورنال
عنوان ژورنال: Cancer Discovery
سال: 2017
ISSN: 2159-8274,2159-8290
DOI: 10.1158/2159-8290.cd-17-0741